Cleavage Liquid-Liquid Extraction Insert
Unique principle based on a hydrophobic or hydrophilic surface treatment of capillary orifice sharply separates immiscible liquids and enables parallel processing of samples using Liquid-Liquid extraction. The absence of a frit or membrane prevents analyte retention.
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Cleavage Liquid-Liquid Extraction Insert
Main unit - cleavage insert contains the sample and features a U-shaped bottom with ultra-fine orifice.
Capillary orifice is chemically treated to be hydrophilic or hydrophobic, allowing selective flow of desired phase.
Second unit - microtube is designed to collect the separated phase.
CLLEVERT was designed in various modifications providing the option to select the best alternative compatible with your protocol.
The separation procedure works either under atmospheric pressure or by centrifugal force. Both variants provide complete and sharp separation within tens of seconds.
Liquid–liquid extraction method is often replaced by Solid Phase Extraction (SPE). However, the SPE columns suffer from high dead volumes in frits and sorbents, causing analyte loss and requiring multiple solvent-intensive steps. On the other hand, the current Liquid–liquid extraction techniques are labor-intensive, largely manual, and difficult to automate. To address these issues, we developed CLLEVERT (Cleavage Liquid–Liquid Extraction Insert), a patented device and method for pre-analytical sample preparation that combines the advantages of SPE and liquid–liquid extraction. The market is projected to expand from USD 450 million to USD 846 million (2023-2033, SPE)[1], and from USD 2.8 billion to USD 4.5 billion (2023-2032, liquid–liquid extraction)[2].
[1] Solid Phase Extraction SPE Market Report | Global Forecast From 2025 To 2033 [2] Liquid Liquid Extraction Equipment Market Report | Global Forecast From 2025 To 2033 (Liquid Liquid Extraction Equipment Market Size, Trends, Industry Outlook & Forecast 2033)
CLLEVERT is a new product that has great sales potential for biomedical and research labs, pharmacies, food science, environmental testing companies, etc.
CLLEVERT can be manufactured in a clean environment using plastic injection molding technology.
Obtain an exclusive license for a predefined area of production and sales with the possibility of sublicensing. The license agreement will be accompanied by a cooperation agreement for the further development of the technology.
(IHBT reserves the right to use the technology for laboratory, research, educational needs and further development of the technology, among other things.)
Contact us for more information. We are ready to present our product to you and further discuss the conditions
of future successful cooperation.
The project is a collaboration between the Institute of Hematology and Blood Transfusion, i&i Prague and Medirekt Partner.
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